Hi kate, regarding your question, yes i have had different results the second go around with some meds. About 5 years ago i was given neurontin and i swore it was making my hair fall out. Tried it off n on several time, same results. Now im taking horizant, an extended release version for the past two weeks with great success. No major hair loss. Also was on tramadol, made me hyper, kept me awake back then. Havent taken it in 3 years. Tried it recently and now it makes me sleepy. Ive been on cymbalta for two yrs. I really dont know howmuch its helping but my new dr said to keep taking it and not to stop. I guess if i were you, if you are unsure about methadone,tell your dr to pick something else. Your previous experience with it sounds extreme and i would be apprehensive to try it again. If your dr insists, maybe try a baby size dose first to see how your system reacts.