I am on board with Neurochic. The animal model does exist but is tricky due to the complex etiology which is immune in some of us and not in others. Animal models for CRPS with allodynia and thermal hyperalgesia usually result from a deliberate constriction injury to the animals sciatic nerve. I hope the little guys sacrifices bring us some relief.

I read recently about the immobilization model including a nerves reaction to ANY form of immobilization including the nerve simply reacting to swelling that alters the way it can glide and transmit information. I found this fascinating.

Before I had a full on CRPS after my third surgery which required NO immobilization, I had flirted with it for a while with my original injury which had a lot of CRPSy features after swelling clunked that nerve down.

So complicated. I hope the supergeniuses get their rest this weekend before heading back to the pain lab on Monday so they can figure this thing out for us.