Oddly enough it was my birthday the other day and my wife said, I don't care what this is gonna do to your nerves have a small scoop of Ice Cream tonight! You have to at least have something bad on your birthday! So, I did. I also decided to take a benadryl while no one was looking in anticipation of what was coming after reading these studies posted here. Normally Ice Cream would've had me up all night in buzzing burning pain (and no, i am not a diabetic). After the Benadryl i had almost no pain that night. I was of course tired as heck! I apted to not take my nightly gabapentin because the benadryl basically seemed to take care of the pain and give me the same groggy reaction. I can't see taking something like Benadryl on a daily basis (especially seeing it can cause low DAO), but in my case it definitely supports the connection of histamine and nerve pain/inflammation.