I'm posting a link to this information I found as I investigate what genetic predisposition I might have to developing breast cancer as a result of HRT. I just had my GYN appointment yesterday, and she knows NOTHING beyond the BRCA gene. Meanwhile, she's upped my does of estrogen (at my request).

Note this company offers the gene test described, so obviously there's a bias.

http://www.estrogengenetest.com/wp-c...troduction.pdf

CYP1A1 Cytochrome P450 1A1
• Fast metabolizers efficiently convert a potentially carcinogenic estrogen, Estrone, to a more desirable estrogen metabolite, 2-OHE1

CYP1B1 Cytochrome P450 1B1
• Fast metabolizers favor the conversion from estrone to a potentially carcinogenic estrogen, 4-OHE1

CYP3A4 Cytochrome P450 3A4
• Fast metabolizers quickly convert estrones to potentially carcinogenic estrogens, 4-OHE1 and 16-OHE1

COMT Catechol-O-methyltransferases
• Slow metabolizers do not convert the potentially carcinogenic estrogen 4-OHE1 to the more favorable 4-MeOE1

GSTP1, GSTM1, GSTT1 Glutathione-S-transferases
• Slow metabolizers or gene deficient individuals do not convert the potentially carcinogenic estrogen 4-OHE1 to the more favorable Glutathione Conjugates

MnSOD Manganese superoxide dismutase
• Reduced MnSOD enzyme activity is associated with potentially genotoxic Free Radical formation