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Old 09-25-2015, 09:18 PM  
janieg
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Join Date: Jan 2014
Location: Maryland
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Originally Posted by janieg View Post
COMT Catechol-O-methyltransferases
Slow metabolizers do not convert the potentially carcinogenic estrogen 4-OHE1
to the more favorable
4-MeOE1

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Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086748/

"In this large population-based case control study, we found no significant overall association between breast cancer risk and COMT haplotypes, although two individual haplotypes, with frequencies of 3.7% and 2.4% in the controls, were significantly associated with decreased breast cancer risk.

A total of six COMT SNPs were genotyped (A total of six COMT SNPs were genotyped (rs1544325, rs174674, rs7290221, rs2239393, rs4680 and rs4646316)."

https://www.23andme.com/you/explorer...name=rs1544325

https://www.23andme.com/you/explorer..._name=rs174674

https://www.23andme.com/you/explorer...name=rs7290221

https://www.23andme.com/you/explorer...name=rs2239393

https://www.23andme.com/you/explorer...np_name=rs4680

https://www.23andme.com/you/explorer...name=rs4646316
__________________
Idiopathic, Full Body, Small Fiber Neuropathy since 11/2013. Symptoms include altered sensation in toes; constant tingling/vibrations in feet and lower legs; intermittent tingling in temples, scalp and face; full body "buzzing" in the morning (suspect mild dehydration); referred sensation in feet cause by touch; occasional bouts with severe cramping in my feet and legs; when flaring, full body burning.

Metabolic issues: FBG -88 A1C - 5.1 with glucose spikes near 300, can't metabolize alcohol, and salt consumption makes my neuropathy 100x worse.

Current treatments:
  • Omega 3's - Fish Oil (2400 mg EPA, 1200mg DHA), 200 mg Magnesium Threonate
  • 5 mg Meribin Biotin for low-normal biotinidase levels.
  • Low carb "back to the farm" diet, lots of water
  • Quell TENS unit, 5% lidocaine patches, magnesium cream, CBD oil
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mrsD (09-25-2015)