Quote:
Originally Posted by janieg
COMT Catechol-O-methyltransferases
• Slow metabolizers do not convert the potentially carcinogenic estrogen 4-OHE1
to the more favorable
4-MeOE1
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Association of COMT Haplotypes and Breast Cancer Risk in Caucasian Women
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086748/
"In this large population-based case control study, we found no significant overall association between breast cancer risk and COMT haplotypes, although two individual haplotypes, with frequencies of 3.7% and 2.4% in the controls, were significantly associated with decreased breast cancer risk.
A total of six COMT SNPs were genotyped (A total of six COMT SNPs were genotyped (rs1544325, rs174674, rs7290221, rs2239393, rs4680 and rs4646316)."
https://www.23andme.com/you/explorer...name=rs1544325
https://www.23andme.com/you/explorer..._name=rs174674
https://www.23andme.com/you/explorer...name=rs7290221
https://www.23andme.com/you/explorer...name=rs2239393
https://www.23andme.com/you/explorer...np_name=rs4680
https://www.23andme.com/you/explorer...name=rs4646316