Thread: Prolotherapy
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Old 09-30-2015, 04:49 AM
Akash Akash is offline
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Join Date: Jul 2014
Posts: 330
8 yr Member
Akash Akash is offline
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Join Date: Jul 2014
Posts: 330
8 yr Member
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Quote:
Originally Posted by kiwi33 View Post
Akash, your link above is indeed "One interesting study" - it seems to me that the authors have summarised the current state of play well.

You also mentioned Lidocaine above - this link discusses its uses and possible side-effects; http://www.drugs.com/pro/lidocaine.html .
Very interesting sir! This is used as a nerve block too? Curiouser and curiouser.
Have you any data on dextrose and nerve interaction by any chance?

This is really surprising.
http://www.ncbi.nlm.nih.gov/pubmed/15920223

Dextrose in water 5% moved nerve response up, whereas lidocaine stopped it!

Perhaps the hypothesis that motivates these guys (but they offer no evidence and only offer a hypothesis):
http://www.jointandspine.com/proloth...-prolotherapy/

I found this one from 1938!!
http://jama.jamanetwork.com/article....ticleid=280518
Six cases of median nerve injuries caused by dextrose. But was it due to the needle and/or the amounts injected?

These guys claim dextrose is all nice and safe
5% dextrose
(D5W) is painless on
injection and does not
cause any long-term sequel in animals or
humans when injected around neurological
tissue (2). - Looks like (2) refers back to the first link by Tsui et al.

http://www.researchgate.net/publicat..._VS_5_dextrose


Facet joint blocks seem to operate on the basis of mix of lidocaine and dextrose
http://drwilderman.com/treatments/in...ck-injections/

Another link - tested dextrose in rabbits to introduce fibrosis to see if that had an effect on the median nerve (is carpal tunnel syndrome actually due to fibrosis); they conclude that dextrose did increase connective tissue (in rabbits) and it did impact median nerve conduction velocity (which makes me wonder how illogical it is to inject folks hands with dextrose to help CTS or are any positive effects due to anti-inflammatory effects postulated?)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706150/
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