Methadone takes about three to four days to get up to a steady state in your blood. Just an FYI so you don't expect miracles in the first few days. It take a long time to get in to your system and a long time to get out of your system. E

I had great success on methadone 5mg tid for my crps. I found it worked much better than other long acting opiods that I tried.

Good luck with it and expect that because of methadone's long half-life you will need a few weeks on the medication before you decide if it is really helping.