My levels were in the 300's. I suspected pernicious anemia and was taking b12. My levels went up but my symptoms did not improve until I started the methyl b12 on an empty stomach. What is noteworthy is that I had the Babinski reflex indicating cns involvement for at least 2 years. On the following neuro exam, after 2 months of methyl b12, I did not have the Babinski reflex. The doctors were totally baffled. I however, because of neurotalk, was not. Immediately, I brought methl b12 for my cousin, who was diagnosed with a very rare progressive only ms, but after 10 years, his Babinski sign is here to stay.

If someone has the MTHFR gene, will b12 shots even work?