I find dosages will vary depending on your activities and stress level...even a bad night sleep or I will notice it if I can't eat a proper meal caused by my swallowing condition... I find it very hard to moderate I just started taking TIMESPAN at bedtime and seems to be helping me get going in the morning hours...I've only been on meds since April of this year, I'm also on Predisone, Imuran 200mg/day and Mestinon 360 to 600mg/day and 1 Plex per week and still have issues with facial and speech issues.