Each drug is different. Amitriptyline is a tricyclic antidepressant and takes at least a month or more to get into the brain to work on pain. It is the only drug so far showing promise in the peripheral system to enhance growth factors and healing.
Gabapentin and lyrica work in the spinal cord to block pain signals coming in from the periphery. So they tend to work faster, but there is no sign of any effects on healing.
They also go to the brain, but seem faster having effects. Gabapentin was designed originally to help reduce seizures.
Everyone is different and everyone has a slightly different cause of PN. There are over 100 causes. So you cannot expect the exact responses someone else tells you they had.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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