Hi there- I am going to a neuro on Monday to get tested for things that might run with a polyclonal IgM and nerve symptoms. i had a bout in 1999, it last six months, went away for 15 yrs and resurfaced in 2013.

a) can the antibodies react like that in a relapse and remit fashion;

b) could they cause the polyclonal Igm themselves OR is there always something else that we don't know about (i.e, a cancer, infection, autoimmune).

c) Also, can this antibody cause CNS issues as well - by that I mean mainly anxiety, racing feelings. Sometimes I think I have some of the paraneoplastic ones b/c those seem to run more with the psychosis, dementia, which is honestly what I feel like CRAZY amounts of anxiety.

I ask b/c Ive been chasing down the source of this igM for 15 years and have gotten ZILCH.