baba222, grape seed ex is not specifically for these neuropathies but addresses so much of our body health issues. It reduces diabetic issues. My friend is getting relief and she's on it as I said 5 yrs or so. I believe she takes at least 200mg daily which is a good dose for most. Some people take more, if you are really really thin one can take less. If you take a pharma blood thinner, you can't take both. Grape seed ex keeps blood thin and cleaner, and so many are on blood thinners today as they have thick dirty blood. I don't know which supplements you take but I would think Omega 3's would be good too, along with the B12 and others many have mentioned here. I take them ALL. Change can happen and often for many subtle. When I started on this antioxidant the sinus/allergy issue cleared up like almost immediately after a previous life of horrid issues and drugs.