Hmmm. I took it for a while, years, then stopped. I started again about a year or so ago. I don't remember why.

If I look it up, I'll remember tho.

Ah, the US National Library of Medicine says this about SAM-e.

Likely effective for...

Depression. Taking SAMe by mouth or by injection seems to reduce symptoms of depression. Several studies have shown that SAMe can be beneficial and might be as effective as some prescription medications used for depression (tricyclic antidepressants). Some research also shows that taking SAMe might be helpful for people who do not have a good response to a prescription antidepressant. However, SAMe should not be taken in combination with a prescription antidepressant without the monitoring of a health professional.

Osteoarthritis. Taking SAMe by mouth seems to work about as well as aspirin and similar medications, but it can take twice as long to start working. Most people with arthritis need to take SAMe for about a month before they feel better.

https://www.nlm.nih.gov/medlineplus/...tural/786.html