Originally Posted by mrsD

Yes, I think they can depending on severity.

The signals from the periphery go to the dorsal roots, along the spine, and those depend on those signals and have a feedback of sorts back down to the origin location. If the sending signals from say, the feet, don't get received, then the dorsal roots forget about sending the feedback signals and the muscles deteriorate.

This goes on all the time at a low level that you normally do not notice. When a kink develops in this feedback, you get twitching, and or cramping sometimes too.