Good point Russell,
I agree and like to be methodical about trying one thing at a time so I know what is working and what isn't. This also helps sort out side effects and dose changes.
After struggling with dizziness and decreasing dose, my nortriptyline is now so low I wondered if it did anything until I tried not taking it for a week!

Wouldn't have thought it would do much but Wow! Not giving that up yet, even with ketamine infusions.