It is easy to break a 100 mg 5-HTP. Most are the long tablets that break easy. I think it would be a good idea to start with 50 mg twice a day. 5-HTP has a very short half life so it does not stay in your blood very long. You can stop the L-Tryp but L-Tryp will not cause an overdose. I take both. The L-Theanine does not interact with the 5-HTP.