Quote:
Originally Posted by Akash
Very interesting sir! This is used as a nerve block too? Curiouser and curiouser.
Have you any data on dextrose and nerve interaction by any chance?
This is really surprising.
http://www.ncbi.nlm.nih.gov/pubmed/15920223
Dextrose in water 5% moved nerve response up, whereas lidocaine stopped it!
Perhaps the hypothesis that motivates these guys (but they offer no evidence and only offer a hypothesis):
http://www.jointandspine.com/proloth...-prolotherapy/
I found this one from 1938!!
http://jama.jamanetwork.com/article....ticleid=280518
Six cases of median nerve injuries caused by dextrose. But was it due to the needle and/or the amounts injected?
These guys claim dextrose is all nice and safe
5% dextrose
(D5W) is painless on
injection and does not
cause any long-term sequel in animals or
humans when injected around neurological
tissue (2). - Looks like (2) refers back to the first link by Tsui et al.
http://www.researchgate.net/publicat..._VS_5_dextrose
Facet joint blocks seem to operate on the basis of mix of lidocaine and dextrose
http://drwilderman.com/treatments/in...ck-injections/
Another link - tested dextrose in rabbits to introduce fibrosis to see if that had an effect on the median nerve (is carpal tunnel syndrome actually due to fibrosis); they conclude that dextrose did increase connective tissue (in rabbits) and it did impact median nerve conduction velocity (which makes me wonder how illogical it is to inject folks hands with dextrose to help CTS or are any positive effects due to anti-inflammatory effects postulated?)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706150/ |
This is all very interesting to read. I came back on this forum after several months maybe even a year or more to see if prolotherapy or prolozone has helped anyone who has severe nerve pain due to TOS. I have a long history - 3 surgeries to the rt side, unsuccessful and made me much worse due to the first one going wrong. I went back to work after 2 years a few months back and I am probably going to have to stop working again. I have been consulting with several doctors about prolo. One doesn't think it will help at all, another said it would just irritate my nerves further which goes along the lines of the concerns you are pointing out. I was actually scheduled for prolozone with Orthohealing center in LA but I keep rescheduling because a) they are charging several hundred for one session and b) I want to make sure if I spend $, it will be on something that won't make me worse. If Dr. Chen only charges $200 per session I will probably just go ahead and do it.
The other thing I have been considering is ketamine infusions, although it is much much more expensive.
At the end of the day, each of us are very different even with the same diagnosis so you have to just weigh the benefits with the costs. Everything is a risk. I can't live like this anymore so I'm leaning toward doing it. Good luck with whatever you decide to do!