Orlistat can interact poorly with vit D.
Call your doctor because he or she needs to know what is going on.
Check with a pharmacist because they are good about looking for interactions.

You made two big changes of large doses at the same time so it is hard to know what is going on.
Maybe ask your doc to stop the D or the 12 so that you can pay attention to symptoms and side effects for a little while of only one of them.