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Patrick Winter · 11-23-2015, 11:28 AM

Quote:

Originally Posted by mrsD

There is very little to be found on the net...about this potential interaction except for the absorption issue at the stomach level.

I did find this very high tech article on rats, involving injecting
directly into the spine...
http://www.ncbi.nlm.nih.gov/pubmed/12766660

I have not found any studies yet on humans.

This drug has been used now for many years, with still vague expanations or no explanations on how it works.

The new theories involve calcium channels... and if this proves to be true, magnesium is a player in regards to the NMDA pain receptors which are calcium driven.

http://www.ncbi.nlm.nih.gov/pubmed/11966555

One would think Big Pharma could provide the needed evidence by now about mechanisms of action?

http://www.ncbi.nlm.nih.gov/pubmed/9551785
This link contains a flurry of possible scenarios.

Magnesium as such is a NMDA antagonist and as such is valuable for pain relief. It might even be BETTER than gabapentin which shows only efficacy for about 30% of the people who use it.

I think at this point documentation of magnesium hindering gabapentin, once absorbed into the blood stream, is not compelling yet.

I'll keep looking later today.

I was told simply that Magnesium keeps Gabapentin from working. Magnesium decreases the body's ability to absorb the medicine. I am in the 30% of people who does receive partial relief from gabapentin.

its also difficult for a lot of people to space it out when they can be on gabapentin regimens where you take the pills every 4 or 5 hours.