@ragtop....

Either that, or the more ominous answer that the drug companies know full well how the drugs work and are just not telling.

The SSRIs were put on the market with no clear understanding of how they work.
Still there is controversy that they don't work at all.

Glaxo was sued by NY State to reveal its negative studies on Paxil and ended up doing so. (resulting in a dramatic drop in the use of Paxil in the US.

We know now that the cardiac damaging effects of Cox-2 inhibitors was known when they were launched. (I had found the prostacyclin effects), even before this drug class was allowed to be sold. So Merck KNEW about the risks.There were sales memos instructing the reps on how to handle questions from doctors. These were shown on 60minutes years ago during the Vioxx scandal. The FDA really is only given bare bones information about drugs these days.

There was a doctor on the Zyprexa clinical trials that shredded data on QT sudden deaths in that study.
more:
http://www.theicarusproject.net/nyt-...rexa-documents

http://neurotalk.psychcentral.com/ar.../t-104025.html

I really find it very difficult to grasp that Big Pharma doesn't know about their own drugs. And shame on the FDA for not being more careful and requesting this withheld information.

I believe that Pfizer already knows all about Lyrica and Neurontin, and is not releasing that information.