I'm just finishing my 3rd week on Azilect (0.5) and haven't really noticed a difference. (I'm on Sinemet 25/100 3x a day as well.) In a week I bump up to 1.0 and maybe then I feel a difference? Most people have told me that it takes anywhere from 4-6 weeks to start to feel a difference on Azilect. I'm hoping that's what happens to me.

Being patient is certainly not one of my better virtues...