We were told that Neurontin takes about 8 weeks to start taking effect, and then becomes increasingly effective with time. It seems like forever, but don't give up on it yet. Having said that, we found Lyrica to be a better option, but it takes some effort on the doctor's part to get insurance to approve it, as it is very expensive. It starts to take effect in just a few days instead of several weeks. Everybody responds differently to meds, so unfortunately, it takes a bit of trial and error to figure out what works.