#1 Some meds dull the pleasure senses as well as dulling the pain signals... so that should be looked into as mentioned by others, maybe a better mix of meds will change things.

#2 Exercise is good , but I do think it sounds like going overboard on it..denial of the condition? Sometimes things can compound into spreading which is a possibility..

# 3 All the exercise & activities is her "outlet"?? ( a convo for you and her)

I would look into a better combo of meds first..