I just wanted to chime in and give you some insight on the LDN. I started taking it in October. I saw a post that Biobased wrote and I started to research it. One of my PM drs wouldn't prescribe it, so I asked another who did some research and then let me do it. I was not on any opiates but took the max of Tramadol each day, which I thought was pointless as i was still in significant pain. I had also stopped taking Cymbalta and Lyrica over the summer because of the horrible side effects.

The Month of November was HELL. It turns out that Tramadol was helping somewhat. I cried a lot. I missed any activity outside of work and sleep and fell into a hopeless feeling I would never get better. I emailed my dr at the beginning of the 5th week saying I couldn't take the pain anymore and couldn't wait for the LDN to work. I ended the email saying I would try to make it a few more days because I had fought for so many weeks waiting for it to work.

And it finally did. Days after I emailed the Dr I began to feel better in the morning. At first I didn't get my hopes up but after a week of feeling good in the am, I was convinced. I have now been on it about 10 weeks and continue to feel better. I take 3.0mg at night and next month would like to go up to 4.5mg and take 1/2 in the am and 1/2 at night since I feel really great in the am and then get worse after 1pm.

I am also on Oral Ketamine for breakthrough pain. I take 25 mg every 4-6 hours. This Ketamine helped save me in those moments of intense pain but it only worked for an hour at most after taking it. (I also just had a 7 day inpatient infusion that worked well)

The LDN is worth it for me. but just have a plan in place to help get you through those first dreadful weeks. Goodluck and keep us posted. hugs.