Hello all.

I had been on Cymbalta + Lamictal and Seroquel for five years and it had helped me with a depression that was caused by chemical imbalance.
Then after years with these meds, they stopped working.

Last year I started to get so depressed again that it came to the point where I can't get out of bed on most days.

I'm in a Partial Hospitalization Program at the moment and two months ago, they've put me on Wellbutrin and Latuda (and took me off the meds that didn't work anymore) - without any success... the depression, fatigue and emotional numbness are still here.

Now they added Effexor to my meds and I'm now taking this following combination: 150 mg Wellbutrin + 150 mg Effexor in the morning, and 120 mg Latuda at night.

It's been 10 days with the Effexor and nothing has changed. It is probably too early to tell, right?
But I'm having real problems getting through each day as I feel completely empty and depleted.... This depression now lasts for one year and I am losing my hope.

Has anyone ever tried Effexor and what was the outcome?
Thank you.