PamelaJune, that sounds really hard for you and DB about his sister.

I don't have much wisdom to offer beyond saying that Seroquel and alcohol is not a good combination.

I have never been in the situation that he is with his sister but all that I can suggest is that you encourage him to look after himself first - that is not a selfish thing to do, he has his own things to deal with and he can not "save" his sister (not suggesting that he wants to do that) though family loyalty is always important.

With care and concern .