I also have Lyme neuropathy. It is very excruciating. Debilitatingly so. I just started on LDN, very low dose to start, 1.5 mg, after Madisongrrl's suggestion. So far so good. Nothing miraculous yet, though. I think it will take some time to see a benefit. Start low and slow and build up. The drug I found that helped me the most was Rifampin, an antibiotic.