February, thank you for that link - it is a very interesting paper.

Here is another free-access paper from the same group http://www.sciencedirect.com/science...28390815300733 and here is the Abstract of another paper http://www.ncbi.nlm.nih.gov/pubmed/26699811.

They all seem to be arguing the same plausible biochemical point; biotin may leading to enhanced activity of acetylCoA carboxylase (which catalyses the first step in fatty acid biosynthesis) as well as pyruvate carboxylase and 3-methylcrotonyl-CoA carboxylase which, in different ways, can lead to increased ATP production.

I hope that larger double-blind studies confirm these reports.

February, as an aside "The B complex should be included with the biotin." - none of the papers mention this - can you explain more?