I should have said, take calcium with magnesium. Calcium is important but problematic without adequate magnesium. They are often sold together.

I have always said to take the minimum amount of 5-HTP to get a benefit. More is not better. If 50 mgs does not help, try 100.

SSRI's can cause high serotonin and other problems. For people who are struggling to have enough serotonin, rather than taking an SSRI, take a small amount of 5-HTP (or L-Tryptophan) and slowly dose up to get benefit. I do very well with 100 mgs. It took high doses of an SSRI to get the same effect.

From ncbi:

Vitamin B6 (pyridoxine) causes neuropathy at intakes of 1000 mg per day or more, which is about 800 times the daily intake from foods. There have also been occasional reports of toxicity at intakes of 100-300 mg per day.

50 mgs is rarely a problem. My doctor recommended more than 50 mgs.

The recommended daily intake of 1-2 mgs is to prevent B-6 deficiency, not to prevent B-6 toxicity. The report linked has cited many maximum doses. 500 mgs or 8 mgs/kg is considered the maximum safe level to avoid a risk of B-6 pathologies. 100 mgs showed a non-statistical difference in some subtle neurological functions.

But, more importantly, the full range of B vitamins is important. Folic acid is important to maintain the blood brain barrier and myelin sheath repair. There are other B vitamin balancing factors that I have read but did not focus on because a B-50 Complex addressed these issues without needing to take individual B vitamins other than supplemental B-12.

Thiamine (B-1) is important, Riboflavin (B-2) is also. And niacin. My doc who started me on the regimen actually had me taking additional thiamine and niacin. He gave me weekly B-12 injections until I was 'over the hump' with my symptoms. From then, I took B-12 supplements.