Rather than dig out individual papers, as I cannot find the ones I had, here is an editorial I recall reading from Annals of Internal Medicine (2013) on vitamin supplementation and measure outcomes linked to controlled and often ranked studies.

Enough is enough: Stop wasting money on vitamin and mineral supplements
http://annals.org/article.aspx?articleid=1789253

Some of the doses, if I recall correctly in the vitamin sticky being recommend to our recommended are highish in nature (note: pretty much every first-time poster is told to follow the vitamin sticky regimen). As the article highlights, danger is in the dose.

Also, I am glad that you are familiar with so many of our community but I think it is likely fair to say that you are not familiar with many of our health dispositions. Assuming that most of the population is the minority for allelic issues, nutrient deficiencies, etc. is not responsible.

The reason why I am speaking up about possible issues linked to vitamin supplementation is that each time I see it being promoted to a member I think of the possible risks that are associated with this regimen. It makes me very uncomfortable, particularly when several of the vitamins being endorsed for daily supplementation have been linked to early mortality and/or cancer.

It is my opinion that people should be presented with information such that they make an informed decision. I think people should be encouraged to work with their physician, endochrinologist, etc. to have tests done so that accurate supplementation, if needed, be used. This may allow some micro/macro-nutrients linked to risks be avoided. This seems sensible and responsible. Having an intensive vitamin regimen associated with high levels of many vitamins and minerals without any risks presented is irresponsible, and, as I said earlier, I'm surprised it is permissible.

Information is always a good thing, and right now the picture of vitamin supplementation here on Neurotalk is not balanced.