I also wouldn't recommend popping 60 capsules, nor is the study that they're currently working on suggesting that (in fact it warns not to do just that... it's not the same grade or quality of biotin and yes that makes a huge difference) but at least one of the good things about biotin is it a water soluble vitamin, making it difficult *not impossible* to get too much of, providing of course you are well hydrated.

However, that is when talking about the normal doses, and not some ultra dose, the equivalency of taking an entire bottle of biotin. There's no real information as yet about how it may concern the various organs when subjected to large doses over an extended period of time. However I would imagine that biotin's effect on body fat would lead to some involvement with the liver, and possibly the kidneys as well.

That said, water soluble vitamins and nutrients are far safer than their fat or organ storing cousins, and are the least likely to lead to any sort of toxicity, barring an underlying condition that may trick them into being stored or prevent them from being adequately flushed through the system.

Only one other concern over the liver and kidneys with excess biotin consumption, is that it is one of the few vitamins which can easily slip through the blood/brain barrier. Leading to the question of whether or not it might end up causing additional neurological problems while fixing the MS. Could it be an out of the pan and into the fire situation, if the long-term dosing of biotin causes some kind of build-up/plaque within the brain tissue or along the nervous system pathways.

That is something we still don't know for sure, which is why it remains in the phase III of testing. The mice and rats have been shown great results, the beginning human trials are showing remarkable results, but we still don't know how much benefit will be gained exactly, nor how long one can subject themselves to it without falling down another slippery path, if ever.