Quote:
Originally Posted by beatle
I was on Lisinopril for 8-9 years, never knew it could cause PN symptoms.
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Some people are genetically prone to this reaction. Partially inactive C-1-inhibitor allows the bradykinin to build up. But people with normal complements 3,4 and C-1 inhibitor may be less likely to react to elevated bradykinin levels. Bradykinin, remains in the cells until an "event" triggers it. It can be prolonged stress, trauma, infection, surgery etc. Bradykinin then comes out of the cells and causing diffuse inflammation, in response to the stressor. People with genetic problems in manufacturing the C-1 inhibitor are the ones to have long term problems with the ACE drugs.
These drugs were synthesized from snake venom.
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Weezie looking at petunias 8.25.2017
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