I was on Toprol XL for blood pressure because I have an abdominal aortic aneurysm. after attending a seminar by dr Goudreau of MSU about 8 months ago, I changed to isradipine 10 mg/day. controls BP the same (avg 129/87) and maybe there will be an effect on PD progression. currently on 800 sinemet IR and 100 sinemet CR (at bedtime). neuro has me monitoring BP throughout the day, and I have no concerning fluctuations. I don't notice any side effect, good or bad from the isradipine.