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Old 01-29-2016, 11:51 AM
DavidHC DavidHC is offline
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Join Date: Nov 2015
Posts: 732
8 yr Member
DavidHC DavidHC is offline
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Join Date: Nov 2015
Posts: 732
8 yr Member
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Thanks, Kiwi. I've read that among other things a few months ago when Amyloidosis was suspected. If I'm not mistaken, the piece I posted, which I'm now going to read in detail, notes many other mutations and not just those two, no? Is it that those two are the most common?

Yes, it can, and my main concern is primary, or even secondary (though to a lesser degree), but my neuro seems to think familial, I'm not sure quite why. We'll see.

Regarding the fat pad biopsy, why do you think I shouldn't concern myself with one? If you mean for familial, I understand, though I could have a mutation that has yet to be recorded. For the non-genetic ones, it's the surest way to diagnose, about 80% or higher precision, short of biopsying the organ itself.

Thanks again for your input and assistance.

Quote:
Originally Posted by kiwi33 View Post
Genetic screening for L55P or V30M is very easy and accurate to do. It would take my lab (we are not a commercial set-up) about a week. I wouldn't worry about a fat pad biopsy.

Neuropathy can be associated with amyloidogenic proteins other than TTR. The information in this link might give you something to think about and discuss with your neurologist; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531896/.
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