I happened upon a great discovery for myself. I started taking these antihistamines in an effort to find something that would improve my sleep - other than highly addictive sleeping pills or the antidepressant and anticonvulsant families. I had severe tolerance issues with three of these and not prepared to risk any more

I often used to take antihistamines regularly for severe eczema and allergies and had some left over unopened from a 2014 prescription. So I thought it worth a try at least as no contraindications with my BP meds - not strong drugs and I've tolerated them before.

Wonder of wonders it seems to help a lot with my neuro and vestibular symptoms! It may just be because of the sedative component of course but even when I wake in the early hours I don't have the burning in my hands half as badly. I just wonder if anyone else knows about this? Hoping it might help others perhaps. Here is what a friend from a lupus forum found out for me.

"Apparently
"Limited clinical evidence shows that [chlorphenamine] is comparable to several antidepressant medications in its ability to inhibit the reuptake of serotonin and also norepinephrine (noradrenaline)."

and

"There are several different classes of medications commonly used to treat neuropathic pain. These include antidepressants, anticonvulsants, opioids, and topical treatments. Tricyclic antidepressants (TCAs) consistently are recommended as first tier drugs across all guidelines ... TCAs consistently were selected as first-tier choices based on their efficacy and other factors such as cost and availability. Their mechanism of action is inhibition of serotonin and norepinephrine reuptake."

Which looks like the link to me.

If there are no interactions/contraindications and it works - seems like an answer. Ask a pharmacist..."