Update 2/01/16: I stopped taking the Topamax and resumed the Indomethacin Saturday PM and by Sunday I was already feeling "better" or at least back to how I was before.

For whatever reason the Topamax strongly disagreed with me and even with a tiny 25mg dose made me feel like I had a stroke or something. Cognitive function was worse than ever.

I guess I will stay on my current course for a while longer.

Are there any natural anti-depressant or mood-elevating supplements anyone would recommend? St Johns Wort? 5HTP? Stuff like that? I'm already taking the basic supplement regimen (B-50 complex, omega-3's, etc).