I was telling my friend who deals with nasty CFS/ME for many yrs about that I'm going to start seriously with 5-HTP and she tells me this morning she's been taking it 12 yrs and thinking about it from my comments, thinks it's helped to get her thru all the years of CFS she lives with. So I kinda anxious to buy it this weekend. One needs to be sure to take B6 with it, so I'll bite a little piece of my P5P off when I take it. Altho, I do take 50mg P5P daily. COULD lift the serotonin, hope hope hope. I'll buy the 50mg caps to start with.