Thread: Just dx'd with genetic variant of sodium channel blocker
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Old 02-07-2016, 10:36 PM
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kiwi33 kiwi33 is offline
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kiwi33 kiwi33 is offline
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Join Date: Jan 2015
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8 yr Member
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Hi Mamadebski

My understanding is that Mexiletine is no longer available. It was initially indicated for management of irregular heartbeat and was sometimes used for management of neuropathy.

It seems that it had many possible adverse side-effects - this is discussed in this old NeuroTalk thread; http://neurotalk.psychcentral.com/ar...hp/t-3441.html.

Which sodium channel mutant do you have - the most common of those linked to peripheral neuropathy are those in Nav1.8 (SCN10A) and Nav1.9 (SCN11A)?

Apparently drugs which may help in this context are under development but it seems that none have been approved yet; http://www.neurologyadvisor.com/pain...rticle/380020/.
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