My comments are about ADDICTION, which food can be. Wellbutrin blocks the pleasure derived from smoking also, and is used for that.
Here is an example of how that works:
Quote:
Eur J Pharmacol. 2007 Jul 12;567(1-2):102-9. Epub 2007 Apr 6.Click here to read Links
Comparison of the effects of bupropion on nicotinic receptor-evoked [(3)H]dopamine release from rat striatal synaptosomes and slices.
Sidhpura N, Redfern P, Wonnacott S.
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
Tobacco smoking is a nicotine addiction, mediated in part by the ability of nicotine to elicit dopamine release, as a result of the stimulation of nicotinic acetylcholine receptors associated with dopaminergic pathways. The smoking cessation agent bupropion is an inhibitor of the dopamine transporter, but has also been shown to inhibit nicotinic acetylcholine receptors. To assess the relative impact of its actions at these two targets, we have examined the effects of bupropion on nicotine-evoked [(3)H]dopamine release from rat striatal synaptosomes and slices, in the absence of any other transporter inhibitor. Bupropion (10 microM) significantly decreased nicotine-evoked [(3)H]dopamine release by approximately 50% in both preparations, consistent with the blockade of nicotinic receptors. In support of this interpretation, bupropion also selectively inhibited nicotine-evoked Ca(2+) increases in SH-SY5Y cells. In striatal slices (but not in synaptosomes) the concentration-response profile for bupropion has an inverted 'u' shape, with a decrease in nicotine-evoked [(3)H]dopamine release also observed in the presence of 0.1 microM bupropion. This effect of 0.1 microM bupropion (but not 10 microM bupropion) was reversed by the dopamine D(2) receptor antagonist raclopride. We propose that modest blockade of the dopamine transporter by low concentrations of bupropion results in feedback inhibition via dopamine D(2) autoreceptors. This is overcome at higher concentrations of bupropion, before inhibition of nicotinic receptors occurs. Therefore bupropion's inhibition of the dopamine transporter and nicotinic receptors appears to be separated with respect to concentration.
PMID: 17477919 [PubMed - in process]
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The whole understanding of neurotransmitter effects is rather beyond this board however.
Here is an example:
http://www.preskorn.com/columns/0001.html
Wellbutrin was delayed in coming to market, because it was not understood well. It has mild dopamine and norepi reuptake effects, but that is not all it does. There are many actions of dopamine and the dopamine transporter.
Wellbutrin will in the body, enhance dopamine effects on the heart as well, and some patients get palpitations from it.
But in my opinion Wellbutrin blocks food pleasure reinforcement and that is distinct from some of its other actions.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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