I did notice some mild improvement after the five days, but it was NOT a huge reduction in symptoms. It takes time for this to work. It basically has to modulate the immune system and it's responses. That loading dose is just the first step. They do like to see some improvement after the loading dose (even just a little), but it doesn't always happen from the people I have talked to. For some, it can be 3-6 months before they notice improvement. But some of these didn't get the 5 day loading dose (some get 3 days and some just start monthly infusions). You'll just have to wait and see. But be optimistic!!