Be sure to hydrate well before the infusion begins...and during those 5 days. Also, make sure to tell the nurse/doctor about ANY side-effects. Most side-effects are rate related and the nurse will slow down the rate if you have any headache, etc. Don't wait until side-effects get bad to bring it up. They need to know right away if you have headache, chills, etc. They will be checking your vitals throughout the infusion as well. This is protocol, so don't be alarmed by them taking pulse, BP every 15-30 minutes at first...and every time they increase the rate a little.