Quote:
Originally Posted by DavidHC
Ragtop,
I'm sorry to hear that your gut issues are acting up again. It's not fun, I know too well. Have you considered SIBO as the root cause? There is leaky gut that's certainly related, and we now see vitamin D plays a role in that it seems. I'm trying to get to the root of mine too, or to try to heal it. I do think it's due to my intestinal permeability that my SFN and other health problems arose...that's my best guess anyway, and it seems like a good one. Anyway, I hope you improve.
I also wanted to thank you for posting about your mutation in the VDR taq gene. I didn't know about this. What does it mean for you? Perhaps it's worth getting myself checked out? I don't think I have difficulty creating D from sunlight, but I could be wrong, since my first ever D serum test was this past November. But I suppose I would have had problems earlier than in my 30s, if I had issues with vitamin D. Perhaps not though, and if vitamin D is connected to the gut, considering I've had those issues for many years, perhaps there is a problem with my ability to produce vitamin D. I'll have to look more into this. Thank you for pointing me to it. I had no idea.
Well, it's frustrating and annoying and all that, true. I also hear you about the need to make medical and health research a second job. It's taking up so much of my time, and I find myself reading more medical literature than my own work. At some point I'll have to slow down. Hopefully you can find a solution to your issue.  |
David:
As you can see from the replies here, the whole genetic aspect of diseases is very complex and frustrating to understand. I had the genetic testing done by 23andme - it costs about $100. You can then run the raw data through various sites to get information on the mutations. The genes related to methylation seem to be of some significance in relation to neurological and digestive issues.
In my case I am +/+ for the VDR taq gene and +/- for the two of the three COMT genes. (I also have a +/+ mutation on the A1298C MTHFR gene) So, I do take supplements and eat foods that contain a lot of methyl donors. Seems to help, but its no magic bullet.
The problem is that there are so many variables, positive and inverse interactions between genes, things that "switch" genes on or off, etc., etc. When I look at all the diseases that are associated with the various mutations I have - I wonder how I even made it the age of 53...........
