Thanks, Ragtop.
This, very much this!
"The problem is that there are so many variables, positive and inverse interactions between genes, things that "switch" genes on or off, etc., etc. When I look at all the diseases that are associated with the various mutations I have - I wonder how I even made it the age of 53."
It's fascinating but so complex, in great part due to the fact that we know so little about the complex interactions/operations at that level.
You know, I was avoiding it, but I may actually go ahead and get the test done. At the same time, I think well I've survived so far, and considering it could be much worse. In fact, if I took better care of myself, I don't think anything genetic would have done me in. The genetics of my family is very good, so clearly I screwed with something on the way...
Quote:
Originally Posted by Ragtop262
David:
As you can see from the replies here, the whole genetic aspect of diseases is very complex and frustrating to understand. I had the genetic testing done by 23andme - it costs about $100. You can then run the raw data through various sites to get information on the mutations. The genes related to methylation seem to be of some significance in relation to neurological and digestive issues.
In my case I am +/+ for the VDR taq gene and +/- for the two of the three COMT genes. (I also have a +/+ mutation on the A1298C MTHFR gene) So, I do take supplements and eat foods that contain a lot of methyl donors. Seems to help, but its no magic bullet.
The problem is that there are so many variables, positive and inverse interactions between genes, things that "switch" genes on or off, etc., etc. When I look at all the diseases that are associated with the various mutations I have - I wonder how I even made it the age of 53...........  |