Thread: Symptom
View Single Post
Old 02-26-2016, 07:10 PM
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
Default

Scottsuff, you write "Happens more toward the end of the day, so Im on going to the off side."

You will have a low in your drug levels just before a new dose takes effect. This will be more apparent when your last dose wears off, because you don't have a new one until the morning. So, I think that your symptom is caused by a lack of levodopa. Perhaps made worse by eating protein close to the final dose.

Like aftermathman I think that your regimen of 4 x 250mg Sinemet per day could be improved by taking more, smaller doses during the day. However, moving to 10 x 100mg Stalevo would be too large a jump to take in one step: Stalevo has about 30% more power than Sinemet. My understanding is that both Stalevo and Sinemet are immediate release, Stalevo lasts longer because it has the extra component entacapone. A controlled release version of Sinemet may also be worth considering.

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With QuoteReply With Quote