Senior Member
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Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
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Senior Member
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
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Scottsuff, you write "Happens more toward the end of the day, so Im on going to the off side."
You will have a low in your drug levels just before a new dose takes effect. This will be more apparent when your last dose wears off, because you don't have a new one until the morning. So, I think that your symptom is caused by a lack of levodopa. Perhaps made worse by eating protein close to the final dose.
Like aftermathman I think that your regimen of 4 x 250mg Sinemet per day could be improved by taking more, smaller doses during the day. However, moving to 10 x 100mg Stalevo would be too large a jump to take in one step: Stalevo has about 30% more power than Sinemet. My understanding is that both Stalevo and Sinemet are immediate release, Stalevo lasts longer because it has the extra component entacapone. A controlled release version of Sinemet may also be worth considering.
John
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Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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