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Originally Posted by banjanti
Sorry for the confusion, I meant drugs that work on GABA neurotransmittion, not a supplement
That would be pregabain and gabapentin from anticonvustant
Pregabain made me twitch so I was assuming that similar family drugs may have similar side effects
I may be wrong of course, but I'll rather try a different drug family first, that's why I was thinking of tricyclic antidepressants
I'm just a bit unsure about QT prolonging on a small dose as I have history of arrhythmia
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from what I see on Google sites, gabapentin does not work on Gaba receptors.
http://www.rxlist.com/neurontin-drug...armacology.htm
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The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. In vitro studies have shown that gabapentin binds with high-affinity to the α2δ subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of gabapentin is unknown.
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OTC Gaba products and RX benzodiazepines (like Valium and Klonopin) are GABA agonists...and bind to the Gaba receptors. So don't expect OTC GABA supplements to help much with pain.
They are marketed to address anxiety and panic attacks.
This article is fairly recent and goes into more detail about gabapentin pharmacology.
http://link.springer.com/article/10....-0057-y#page-1
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