Pregabalin shares some chemistry with gabapentin. There are slight differences but Gabapentin is its precursor. Pregabalin was basically developed to do what gabapentin does without the absorbability problem. it absorbs faster and is retained longer with better efficacy. Does it really work for neuropathy as all these TV ads claim? i personally dont see it. it just zombifies you. I have taken both and Lyrica offered some (and i mean small) relief but the side effects outweighed the benefits.