Olsen, thanks for posting this. I think it is an important result. If it is confirmed, it will force a change of direction for much on-going research.

As I understand it, one of the leading contenders to explain PD was that in PwP alpha-synuclein formed fibrils and these aggregated together to form Lewy Bodies. It followed that a potential therapy could involve taking substances such as mannitol, curcumin and cumin which reduce the rate of alpha-synuclein fibrillation.

The present finding shows that the situation is more complex than simple alpha-synuclein is good, while complex alpha-synuclein is bad. This finding is a set-back, because it shows that we do not understand the pathogenesis of the disease.

I've been supplementing my normal diet with turmeric and cumin seeds in the hope that this would slow the fibrillation and, hence, the progression of the disease. Now is time for a rethink,

John