If this study is valid, then use of monoclonal antibodies like Prothena's PRX002 or another from Affiris Inc. would be the way to go. These vaccines remove soluble α-synuclein which is supposedly toxic to cells. On the other hand this new finding makes me feel more cautious in choosing experimental or non-proven therapies - too much uncertainty and unknown about the mechanisms involved into the pathogenesis of the disease. Even supplements most of us are taking could be questioned, as John mentioned in his post (assuming they work). I also recall that I saw some additional infos suggesting that soluble α-syn is a main offender.