that's an interesting observation on stalevo niggs, i added ENTACAPONE to my 150mg- 200mg sinemet only drug regime, with the goal of getting at least 3 hours of on time but quit after 4 days because i was feeling much worse in kind of a hard to describe way, more nausea, fatigue. i did get maybe 30min. of more on time but it wasn't "quality" on time. i mentioned that i was dropping the entacapone to my neuro and he said ok, no encouragement to give it more time but i think he feels i'm ready for DBS and nothing i do in terms of adjusting drugs is going to make much difference. i might try entacapone again based on your experience. i've given up on everything else i've tried if i felt worse in the first few days. amantadine was my worse experience, couldn't sleep and had no appetite,

has DBS been brought up to you, just curious when the brits think it is time.